Publications

2009 and Earlier

Revealing human disease genes through analysis of the yeast mitochondrial proteome.
Hao HX, Rutter J.
Cell Cycle. 2009 Dec 15;8(24):4007-8. Epub 2009 Dec 29. No abstract available.
PMID: 19949294

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J.
Science. 2009 Aug 28;325(5944):1139-42. doi: 10.1126/science.1175689. Epub 2009 Jul 23.
PMID: 19628817

Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Fontés G, Semache M, Hagman DK, Tremblay C, Shah R, Rhodes CJ, Rutter J, Poitout V.
Diabetes. 2009 Sep;58(9):2048-58. doi: 10.2337/db08-0579. Epub 2009 Jun 5.
PMID: 19502418

Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.
Grose JH, Sundwall E, Rutter J.
Cell Cycle. 2009 Jun 15;8(12):1824-32. Epub 2009 Jun 20.
PMID: 19440050

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.
Beumer KJ, Trautman JK, Bozas A, Liu JL, Rutter J, Gall JG, Carroll D.
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19821-6. doi: 10.1073/pnas.0810475105. Epub 2008 Dec 8.
PMID: 19064913

The role of PAS kinase in regulating energy metabolism.
Hao HX, Rutter J.
IUBMB Life. 2008 Apr;60(4):204-9. doi: 10.1002/iub.32. Review.
PMID: 18344204

Yeast PAS kinase coordinates glucose partitioning in response to metabolic and cell integrity signaling.
Grose JH, Smith TL, Sabic H, Rutter J.
EMBO J. 2007 Nov 28;26(23):4824-30. Epub 2007 Nov 8.
PMID: 17989693

PAS kinase is required for normal cellular energy balance.
Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J.
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15466-71. Epub 2007 Sep 18.
PMID: 17878307

Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation.
Smith TL, Rutter J.
Mol Cell. 2007 May 25;26(4):491-9.
PMID: 17531808

Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1.
Mehlgarten C, Zink S, Rutter J, Schaffrath R.
FEMS Yeast Res. 2007 Aug;7(5):722-30. Epub 2007 Mar 16.
PMID: 17367514

Whence cometh the allosterome?
Lindsley JE, Rutter J.
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10533-5. Epub 2006 Jul 3.
PMID: 16818878 [PubMed - indexed for MEDLINE] Free PMC Article

Control of mammalian glycogen synthase by PAS kinase.
Wilson WA, Skurat AV, Probst B, de Paoli-Roach A, Roach PJ, Rutter J.
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16596-601. Epub 2005 Nov 7.
PMID: 16275910

Nutrient sensing and metabolic decisions.
Lindsley JE, Rutter J.
Comp Biochem Physiol B Biochem Mol Biol. 2004 Dec;139(4):543-59. Review.
PMID: 15581787

Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose.
da Silva Xavier G, Rutter J, Rutter GA.
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8319-24. Epub 2004 May 17.
PMID: 15148392

Essay: Amersham Biosciences and Science Prize. PAS domains and metabolic status signaling.
Rutter J.
Science. 2002 Nov 22;298(5598):1567-8. No abstract available.
PMID: 12446897

NPAS2: a gas-responsive transcription factor.
Dioum EM, Rutter J, Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA, McKnight SL.
Science. 2002 Dec 20;298(5602):2385-7. Epub 2002 Nov 20.
PMID: 12446832

Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.
Amezcua CA, Harper SM, Rutter J, Gardner KH.
Structure. 2002 Oct;10(10):1349-61.
PMID: 12377121

Coordinate regulation of sugar flux and translation by PAS kinase.
Rutter J, Probst BL, McKnight SL.
Cell. 2002 Oct 4;111(1):17-28.
PMID: 12372297

Metabolism and the control of circadian rhythms.
Rutter J, Reick M, McKnight SL.
Annu Rev Biochem. 2002;71:307-31. Epub 2001 Nov 9. Review.
PMID: 12045099

PubMed Listing

Click here for a complete list, including the most current publications.

Recent Publications

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.
Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J.
Elife. 2016 Sep 23;5. pii: e17985. doi: 10.7554/eLife.17985.

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis.
Van Vranken JG, Jeong MY, Wei P, Chen YC, Gygi SP, Winge DR, Rutter J.
Elife. 2016 Aug 19;5. pii: e17828. doi: 10.7554/eLife.17828.

Power2: The power of yeast genetics applied to the powerhouse of the cell.
Rutter J, Hughes AL.
Trends Endocrinol Metab. 2015 Jan 12. pii: S1043-2760(14)00204-5. doi: 10.1016/j.tem.2014.12.002. [Epub ahead of print] Review.
PMID: 25591985

Protein-mediated assembly of succinate dehydrogenase and its cofactors.
Van Vranken JG, Na U, Winge DR, Rutter J.
Crit Rev Biochem Mol Biol. 2014 Dec 9:1-13. [Epub ahead of print]
PMID: 25488574

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer.
Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J.
Mol Cell. 2014 Nov 6;56(3):414-24. doi: 10.1016/j.molcel.2014.09.025. Epub 2014 Oct 21.
PMID: 25458842

PAS kinase drives lipogenesis through SREBP-1 maturation.
Wu X, Romero D, Swiatek WI, Dorweiler I, Kikani CK, Sabic H, Zweifel BS, McKearn J, Blitzer JT, Nickols GA, Rutter J.
Cell Rep. 2014 Jul 10;8(1):242-55. doi: 10.1016/j.celrep.2014.06.006. Epub 2014 Jul 4.
PMID: 25001282

SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.
Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter J.
Cell Metab. 2014 Aug 5;20(2):241-52. doi: 10.1016/j.cmet.2014.05.012. Epub 2014 Jun 19.
PMID: 24954416

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.
Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J.
EMBO J. 2014 Jul 17;33(14):1548-64. doi: 10.15252/embj.201487943. Epub 2014 May 19.
PMID: 24843043

Pressing mitochondrial genetics forward.
Chen YC, Rutter J.
Cell Rep. 2014 May 8;7(3):599-600. doi: 10.1016/j.celrep.2014.04.028.
PMID: 24813868

Hallmarks of a new era in mitochondrial biochemistry.
Pagliarini DJ, Rutter J.
Genes Dev. 2013 Dec 15;27(24):2615-27. doi: 10.1101/gad.229724.113. Review.
PMID: 24352419

The long and winding road to the mitochondrial pyruvate carrier.
Schell JC, Rutter J.
Cancer Metab. 2013 Jan 23;1(1):6. doi: 10.1186/2049-3002-1-6.
PMID: 24280073

Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.
Semache M, Zarrouki B, Fontés G, Fogarty S, Kikani C, Chawki MB, Rutter J, Poitout V.
J Biol Chem. 2013 Aug 23;288(34):24825-33. doi: 10.1074/jbc.M113.495945. Epub 2013 Jul 12.
PMID: 23853095

Intramolecular interactions control Vms1 translocation to damaged mitochondria.
Heo JM, Nielson JR, Dephoure N, Gygi SP, Rutter J.
Mol Biol Cell. 2013 May;24(9):1263-73. doi: 10.1091/mbc.E13-02-0072. Epub 2013 Mar 6.
PMID: 23468520  Free PMC Article

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.
Science. 2012 Jul 6;337(6090):96-100. doi: 10.1126/science.1218099. Epub 2012 May 24.
PMID: 22628558

Proliferation and metabolism: it's as easy as APC.
Tantin D, Rutter J.
Cell Metab. 2012 Apr 4;15(4):413-4. doi: 10.1016/j.cmet.2012.03.012.
PMID: 22482721

Identification of a protein mediating respiratory supercomplex stability.
Chen YC, Taylor EB, Dephoure N, Heo JM, Tonhato A, Papandreou I, Nath N, Denko NC, Gygi SP, Rutter J.
Cell Metab. 2012 Mar 7;15(3):348-60. doi: 10.1016/j.cmet.2012.02.006.
PMID: 22405070

PAS kinase promotes cell survival and growth through activation of Rho1.
Cardon CM, Beck T, Hall MN, Rutter J.
Sci Signal. 2012 Jan 31;5(209):ra9. doi: 10.1126/scisignal.2002435.
PMID: 22296835

PAS kinase: integrating nutrient sensing with nutrient partitioning.
Cardon CM, Rutter J.
Semin Cell Dev Biol. 2012 Aug;23(6):626-30. doi: 10.1016/j.semcdb.2011.12.007. Epub 2012 Jan 8. Review.
PMID: 22245833

Revealing the allosterome: systematic identification of metabolite-protein interactions.
Orsak T, Smith TL, Eckert D, Lindsley JE, Borges CR, Rutter J.
Biochemistry. 2012 Jan 10;51(1):225-32. doi: 10.1021/bi201313s. Epub 2011 Dec 9.
PMID: 22122470

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontés G, Philippe J, Meur G, Diraison F, Sessions RB, Rutter J, Poitout V, Froguel P, Rutter GA.
J Biol Chem. 2011 Dec 23;286(51):44005-14. doi: 10.1074/jbc.M111.254995. Epub 2011 Nov 7.
PMID: 22065581

Mitochondrial quality control by the ubiquitin-proteasome system.
Taylor EB, Rutter J.
Biochem Soc Trans. 2011 Oct;39(5):1509-13. doi: 10.1042/BST0391509. Review.
PMID: 21936843

Ubiquitin-dependent mitochondrial protein degradation.
Heo JM, Rutter J.

Int J Biochem Cell Biol. 2011 Oct;43(10):1422-6. doi: 10.1016/j.biocel.2011.06.002. Epub 2011 Jun 12. Review.
PMID: 21683801

A stress-responsive system for mitochondrial protein degradation.
Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J.
Mol Cell. 2010 Nov 12;40(3):465-80. doi: 10.1016/j.molcel.2010.10.021.
PMID: 21070972

Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
Kikani CK, Antonysamy SA, Bonanno JB, Romero R, Zhang FF, Russell M, Gheyi T, Iizuka M, Emtage S, Sauder JM, Turk BE, Burley SK, Rutter J.
J Biol Chem. 2010 Dec 24;285(52):41034-43. doi: 10.1074/jbc.M110.157594. Epub 2010 Oct 13.
PMID: 20943661

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.
An R, da Silva Xavier G, Semplici F, Vakhshouri S, Hao HX, Rutter J, Pagano MA, Meggio F, Pinna LA, Rutter GA.
Biochem Biophys Res Commun. 2010 Aug 20;399(2):155-61. doi: 10.1016/j.bbrc.2010.07.035. Epub 2010 Jul 15.
PMID: 20637728

Succinate dehydrogenase - Assembly, regulation and role in human disease.
Rutter J, Winge DR, Schiffman JD.
Mitochondrion. 2010 Jun;10(4):393-401. doi: 10.1016/j.mito.2010.03.001. Epub 2010 Mar 10. Review.
PMID: 20226277

The role of PAS kinase in PASsing the glucose signal.
Grose JH, Rutter J.

Sensors (Basel). 2010;10(6):5668-82. doi: 10.3390/s100605668. Epub 2010 Jun 4. Review.
PMID: 22219681