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University of Utah

Department of Biochemistry

Bioscience Calendar

Navigen

Life elevated

See images of what Utah has to offer and see why you should consider attending U of U.

Opportunities for Students

Graduate students can join the lab through the programs in Molecular Biology or Biological Chemistry. We welcome rotation students.

Papers

Research from the Kay Lab is published in leading scientific journals. Below are some of our more recent papers. Our complete list is also available.

Helping Hand Overcomes Solubility Challenges in Chemical Protein Synthesis (2016) JACS

 

Universal ebola mirror-image drug target (2016 Protein Science Best Paper Award Winner)

 

Breakthrough in the production of active mirror-image proteins (2014) Proc. Natl. Acad. Sci. USA

 

Membrane Localized D-peptide Inhibitors of HIV Entry (2012) Bioconjugate Chem.

 

Research

The Kay Lab is dedicated to finding ways to combat HIV infection and other life threatening diseases. Our research sheds light on the mechanisms of enveloped viral entry and its inhibition. Through a collaboration with a local pharmaceutical company, Navigen, we hope to translate our research into the development of effective human therapeutics.

The Kay Lab is also interested in developing chemical and conformational tools to break the barriers of solid-phase peptide synthesis (SPPS), allowing larger and more complex chemically synthesized peptides to be prepared for our drug discovery efforts. Ultimately, we hope to tackle this obstacle biologically by assembling a mirror-image in vitro translation apparatus (D-ribosome) and eventually a mirror-image organism (“D. coli”).

Inhibiting Ebola Entry

D-peptide Inhibitors of HIV Entry

The D. coli Project

University of Utah, Department of Biochemistry, 15 N Medical Drive East RM 4100, Salt Lake City, UT 84112-5650 USA

Office: (801) 585-5021 | Lab: (801) 585-9512 | kay@biochem.utah.edu