References:Selected Publications (most reviews omitted) Present to 1993:

Khalimonchuk, O., Rigby, K., Bestwick, M., Pierrel, F., Cobine, P.A. and Winge, D.R. (2008) " Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae", Eukaryotic Cell, in press

Pierrel, F., Khalimonchuk, O., Cobine, P.A., Bestwick, M. and Winge, D.R. (2008)
"Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis facilitating the maturation of Cox1", Mol. Cell Biol. in press

Rigby, K., Cobine, P.A., Khalimonchuk, O. and Winge, D.R. (2008) " Mapping the Functional Interaction of Sco1 and Cox2 in Cytochrome Oxidase Biogenesis ", J. Biol. Chem. 283,15015-15022. Abstract

Kumanovics, A., Chen, O.S., Li, L. Bagley, D., Adkins, E.M., Lin, H., Dringra, N.N., Outten, C.E., Keller, G., Winge, D. Ward, Kaplan, J. (2008) "Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis", J. Biol. Chem. 283, 10276-10286. Abstract

Jouihan, H.A., Cobine, P.A., Hoagland, E.A., Boudina, S., Abel, E.D., Winge, D.R. and McClain, D.A. (2008) “Iron-Mediated Inhibition Of Mitochondrial Manganese Uptake Mediates Mitochondrial Dysfunction In A Mouse Model Of Hemochromatosis”, Mol. Medicine 14, 98-108. Abstract

Son, M., Leary, S.C., Romain, N., Pierrel, F., Winge, D.R., Haller, R.G. and Elliott, J.L. (2008) "Isolated cytochrome c oxidase deficiency in G93A SOD1 mice over-expressing CCS protein", J. Biol. Chem. 283, 12267-12275. Abstract

Khalimonchuk, O. and Winge, D.R. (2008) "Function of Cx9C motif proteins within the intermembrane space that are important in the assembly of cytochrome c oxidase" BBA - Molecular Cell Research, 1783, 618-628. Abstract

Khalimonchuk, O., Bird, A. and Winge, D.R. (2007) "Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase", J. Biol. Chem. 282, 17442-17449. Abstract

Leary, S.C. and Winge, D.R. (2007) “The Janus face of copper: its expanding roles in biology and the pathophysiology of disease. Meeting on Copper and Related Metals in Biology”, EMBO Rep. 8, 224-227. Abstract

Rigby, K., Zhang, L., Cobine, P.A., George G.N. and Winge, D.R. (2007) “Characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiae”, J. Biol. Chem. 282, 102333-102342. Abstract

Pierrel, F., Cobine, P.A. and Winge, D.R. (2007) “Metal ion availability in mitochondria”, Biometals 20, 675-682. Abstract

Coyne H.J. 3rd, Ciofi-Baffoni S., Banci L., Bertini I., George G.N. and Winge, D.R. (2007) “The characterization and role of zinc binding in yeast Cox4”, J. Biol. Chem. 282, 8926-8934. Abstract

Wu, C.-Y., Bird, A.J., Winge, D.R. and Eide, D.J. (2007) “Regulation of the yeast Tsa1 peroxiredoxin by Zap1 is an adaptive response to the oxidative stress of zinc deficiency”, J. Biol. Chem. 282, 2184-2195. Abstract

Leary, S.C., Cobine, P.A., Kaufman, B.A., Guercin, G.-H., Mattman, A., Palaty, J., Lockitch, G., Winge, D.R., Rustin, P., Horvath, R., Shoubridge, E.A. (2007) “The human cytochrome c oxidase assembly proteins SCO1 and SCO2 are involved in the regulation of cellular copper homeostasis” Cell Metabolism. 5, 9-20. Abstract.

Qiao, W., Mooney, M., Bird, A.J., Winge, D.R. and Eide, D.J. (2006) “Zinc binding to a regulatory zinc-sensing domain monitored in vivo using fluorescence resonance energy transfer”, Proc. Natl. Acad. Sci. USA. 103, 8674-8679. Abstract

Bird, A.J., Gordon M., Eide D.J., Winge D.R. (2006) "Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts", EMBO J. 25, 5726-34. Abstract

Bird, A.J., Swierczek, S., Qiao, W., Eide, D.J. and Winge, D.R. (2006) “Zinc metalloregulation of the zinc finger pair domain” J. Biol. Chem. 281, 25326-25335. Abstract

Cobine, P.A. and Winge, D.R. (2006) “Visualizing the tri-coordinate copper intermediate in a copper transfer reaction” Nature Chemical Biology. 2, 352-353. Abstract

Cobine, P.A., Pierrel, F., Bestwick, M. and Winge, D.R. (2006) “Mitochondrial matrix copper complex used in metallation of cytochrome oxidase and superoxide dismutase”, J. Biol. Chem. 281, 36552-36559. Abstract

Ojeda, L., Keller, G., Rutherford, J.C., Muhlenhoff, U., Lill, R., and Winge, D.R. (2006) “Role of glutaredoxin-3 and glutaredoxin-4 in the iron-regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae”, J. Biol. Chem., 281, 17661-17669. Abstract

Cobine, P.A., Pierrel, F., Leary, S.C., Sasarman, F., Horng, Y.C., Shoubridge, E.A., and Winge, D.R. (2006) “The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding”, J. Biol. Chem. 281, 12270-12276. Abstract

Yang, M., Cobine, P.A., Naranuntarat, A., Winge, D.R. and Culotta, V.C. (2006) “The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2”, EMBO J. 25, 1775-1783. Abstract

Cobine, P.A., Pierrel, F. and Winge, D.R. (2006) “Copper trafficking to the mitochondrion and assembly of copper metalloenzymes”, BBA -Molecular Cell Research. 1763, 759-772. Abstract

Horng, Y.-C., Leary, S.C., Cobine, P.A., Young, F.B.J., George, G.N., Shoubridge, E.A., and Winge, D.R. (2005) “Human Sco1 and Sco2 function as copper-binding proteins” J. Biol. Chem. 280, 34113-34122. Abstract

Keller, G., Bird, A.J. and Winge, D.R. (2005) “Independent Metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae” Eukaryotic Cell, 4,1863-1871. Abstract

Carr, H.S., Maxfield, A.B., and Winge, D.R. (2005) “Functional analysis of the Domains of Cox11”, J. Biol. Chem. 280, 22664-22669. Abstract

Herbig, A., Bird, A.J., McCall, K., Mooney, M., Wu, C.-Y., Winge, D.R. and Eide, D.J. (2005) “Zap1 activation domain 1 and its role in controlling gene expression in response to cellular zinc status”, Molecular Microbiology, 57, 834-846. Abstract

Arnesano, F., Balatri, E., Banci, L., Bertini, I. and Winge, D.R. (2005) "Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding", Structure. 13, 713-722. Abstract

Rutherford, J.C., Ojeda, L., Balk, J., Muhlenhoff, U., Lill, R., and Winge, D.R. (2005) "Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial, but not cytosolic iron-sulfur protein biogenesis”, J. Biol. Chem. 280, 10135-10140. Abstract

Chen, O.S., Crisp, R.J., Valachovic, M., Bard, M., Winge, D.R. and Kaplan, J. (2004) “Transcription of the yeast iron regulon responds not directly to iron but rather to iron-sulfur cluster biosynthesis”, J. Biol. Chem. 279, 29513-29518. Abstract

Horng, Y.-C., Cobine, P.A., Maxfield, A.B., Carr, H.S., and Winge, D.R. (2004) “Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome c oxidase”, J. Biol. Chem. 279, 35334-35340. Abstract

Bird, A.J., Blankman, E., Stillman, D.J., Eide, D.J. and Winge, D.R. (2004) “The Zap1 transcriptional activator functions as a repressor by binding downstream of the TATA box in ZRT2 ”, EMBO J. 23, 1123-1132. Abstract

Maxfield, A., Heaton, D.N. and Winge, D.R. (2003) “Cox17 is functional when tethered to the mitochondrial inner membrane”, J. Biol. Chem. 279, 5072-580. Abstract

Cobine, P., Ojeda, L., Rigby, K.M. and Winge, D.R. (2003) “Yeast contain a nonproteinacious pool of copper in the mitochondrial matrix”, J. Biol. Chem. 279, 14447-14455. Abstract

Bird, A.J., McCall, K., Kramer, M., Blankman, E., Winge, D.R. and Eide, D.J. (2003), “ Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function”, EMBO J. 22, 5137-5146. Abstract

Winge, D.R. (2003) “Let's Sco1, Oxidase! Let's Sco!”, Structure. 11, 1313-1314.Abstract

Rutherford, J.C., Jaron, S., and Winge, D.R. (2003) "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements", J. Biol. Chem. 278, 27636-27643. Abstract

Carr, H.S. and Winge, D.R. (2003) "Assembly of Cytochrome c Oxidase within the Mitochondrion", Accounts Chem. Res. 36, 309-316. Abstract

M Evans-Galea, E Blankman, D Myszka, D Eide, and DR Winge, (2003) "Two of the five zinc finger motifs in the Zap1 transcription factor dominate site-specific DNAbinding", Biochemistry. 42, 1053-1061. Abstract

Romero-Isart, N., Jensen, L.T., Zerbe, O., Winge, D.R. and Vasak, M. (2002) "Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1", J. Biol. Chem. 277, 37023-37028. Abstract

Carr, H.S., George, G.N., and Winge, D.R. (2002) "Yeast Cox11, a protein essential for cytochrome c oxidase function is a Cu(I) binding protein", J. Biol. Chem. 277, 31237-31242. Abstract

Winge, D.R. (2002) "Copper Metalloregulation of Gene Expression", Adv. Prot. Chem. 60, 51-92. Abstract

Daniels, P., Bittel, D., Smirnova, I.V., Winge, D.R., Andrews, G.K., (2002) "Mammalian metal response element-binding transcription factor-1 functions as a zinc sensor in yeast but not as a sensor of cadmium or oxidative stress", Nucl. Acid Res. 30, 3130-3140. Abstract

Brown K.R., Keller G.L., Pickering I.J., Harris H.H., George G.N., and Winge D.R. (2002) "The Structure of the Cuprous-Thiolate Clusters of the Ace1 and Mac1 Transcriptional Activators", Biochemistry 41, 469-6476. Abstract

Rutherford J.C., Jaron S., Ray E., Brown P.O., and Winge D.R. (2001) " A Second Iron- Regulatory System in Yeast Independent of Aft1p", Proc. Natl. Acad. Sci. USA. 98, 14322-14327. Abstract

Nittis T., George G.N., and Winge D.R. (2001) "Yeast Sco1, a Protein Essential for Cytochrome c oxidase Function is a Cu(I)-binding Protein", J. Biol. Chem. 276, 42520-42526. Abstract

Keller G.L., Ray E., Brown P.O., and Winge D.R. (2001) "Haa1, a Protein Homologous to the Copper-Regulated Transcription Factor Ace1, is a Functiona1 and Novel Transcriptional Activator", J. Biol Chem 276, 38697-38702. Abstract

Heaton D., George G.N., Garrison G., and Winge D.R. (2001) "The Mitochondrial Copper Metallochaperone Cox17 exists as an Oligomeric, Polycopper Complex",Biochemistry 49, 743-751. Abstract

D Heaton, T Nittis, C Srinivasan, DR Winge, "Mutational Analysis of the Mitochondrial Copper Metallochaperone Cox17", J BiolChem 275, 37582-37587 (2000).Abstract

DW Hasler, LT Jensen, O Zerbe, DR Winge, & MVasak, "Effect of the two conserved prolines of human growth inhibitoryfactor (MTIII) on its biological activity and structure dynamics: comparisonwith a mutant protein", Biochemistry 39, 14567-14575 (2000). Abstract

AJ Bird, H Zhao, LT Jensen, C Srinivasan, M.V. Evans-Galea, DR Winge,& DJ Eide, "A dual role for zinc fingers in both DNA binding and zincsensing by the zinc responsive Zap1 transcriptional activator", EMBO J. 19, 3704-3713 (2000).Abstract

C Gross, M Kelleher, VR Iyer, PO Brown, & DRWinge, "Identification of the Copper Regulon in Saccharomyces cerevisiaebyDNA Microarrays", J. Biol. Chem. 275, 32310-32316 (2000).Abstract

G Keller, C Gross, M Kelleher & DR Winge "Functional Independence of the two Cysteine-Rich Activation Domains in the Yeast Mac1Transcription Factor", J. Biol. Chem. 275, 29193-29199 (2000). Abstract

AJ Bird, MV Evans-Galea, E Blankman, H Zhao, H Luo,DR Winge, & DJ Eide, (2000) "Mapping the DNA binding domain of the Zap1 zinc-responsivetranscription activator", J. Biol. Chem. 275, 16160-16166 (2000).Abstract

P Faller, DW Hasler, O Zerbe, S Klauser, DR Winge& M Vasak, (1999) "Evidence for a dynamic structure of human neuronal growthinhibitory factor and for major rearrangements of its metal-thiolate clusters", Biochemistry. 113, 10158-10167.Abstract

CP McDaniels, LT Jensen, C Srinivasan, DR Winge &TD Tullius, (1999) "The yeast transcription factor Mac1 binds to DNA in a modular", J. Biol. Chem. 274, 26962-26967. Abstract

LT Jensen & DR Winge, "Identification of a Copper-InducedIntramolecular Interaction in the Transcription Factor Mac1 from Saccharomycescerevisiae", EMBO J 17, 5400-5408 (1998).Abstract

LT Jensen, J Peltier & DR Winge, "Identification of a Four Copper Folding Intermediate in Mammalian Cu Metallothionein byElectrospray Ionization Mass Spectrometry", J Biol Inorg Chem 3,627-631 (1998). Abstract

LT Jensen, MC Posewitz, C Srinivasan & DR Winge,"Mapping of the DNA Binding Domain of the Transcription Factor Mac1 fromSaccharomyces cerevisiae", J. Biol. Chem. 273, 23805-23811(1998).Abstract

LJ Martins, LT Jensen, JR Simon, G Keller & DRWinge, "Metalloregulation of FRE1 and FRE2 Homologs in Saccharomycescerevisiae", J. Biol. Chem. 273, 23716-23721 (1998).Abstract

R Turner, D Smith, M Zawrotny, M Summer, M Posewitz& D Winge, "Solution Structure of a Zn-Domain Conserved in Yeast Cu-RegulatedTranscription Factors", Nature Struct Biol 5, 9-13 (1998).Abstract

DR Winge, LT Jensen & C Srinivasan, "Metal Ion Regulation of Gene Expression in Yeast", Current Opinion in ChemicalBiology 2, 216-221 (1998).Abstract

C Srinivasan, MC Posewitz, GN George & DR Winge,"Characterization of the Copper Chaperone Cox17 of Saccharomyces cerevisiae",Biochemistry 37: 7572-7577, (199.Abstract

JA Graden & DR Winge, "Copper-Mediated Repressionof the Activation Domain in the Yeast Mac1 Transcription Factor", ProcNatl Acad Sci USA 94, 5550-5555, (1997). Abstract

M Posewitz, JR Simon, RA Farrell, & DR Winge,"Role of the Conserved Histidines in the Zn Module of the Copper-ActivatedTranscription Factors in Yeast", J Biol Inorg Chem 560-566 (1996).

DR Winge, JA Graden, MC Posewitz, LJ Martins, &J Simon, "Sensors that Mediate Copper-Specific Activation and Repressionof Gene Expression", J Biol Inorg Chem 2-10 (1996).

J Graden, M Posewitz, J Simon, G George, I Pickering,& D Winge, "Presence of a Cu(I)-Thiolate Regulatory Domain in theCu-Activated Transcription Factor, Amt1", Biochem 35:14583-14589(1996).Abstract

LT Jensen, WR Howard, JJ Strain, DR Winge, & VCCulotta, "Enhanced Effectiveness of CUP1 Metallothionein Compared to CRS5Metallothionein in Copper Ion Buffering in Saccharomyces cerevisiae.J. Biol. Chem. 271, 18514-18519 (1996). Abstract

W Yu, DJ Stillman & DR Winge, "Identificationof SLF1 as a new copper homeostasis gene in S. cerevisiae involvedin copper sulfide mineralization", Mol Cell Biol 16, 2464-2472,(1996)Abstract

R Farrell, J Thorvaldsen, A Sewell, & DR Winge,"Identification of the Zn(II) Site in the Copper-Responsive Yeast TranscriptionFactor, AMT1: a Conserved Zn(II) Module", Biochem 35,1571-1580(1996). Abstract

GC Perez-Alvarado, J Kosa, HA Louis, MC Beckerle,DR Winge, and MF Summers, "Structure of the Cysteine-Rich Intestinal Protein,CRIP", J Mol Biol 257, 153-174 (1996)Abstract

J Thorvaldsen, R Mehra, W Yu, A Sewell, & DR Winge,"Analysis of Copper-Induced Metallothionein Expression using AutonomouslyReplicating Plasmids in Candida glabrata" Yeast, 11,1501-1511, (1995).Abstract

A Sewell, F Yokoya, Y Wei, T Miyagawa, T Murayama& D Winge, "Mutated Yeast Heat Shock Transcription Factor ExhibitsElevated Basal Transcriptional Activation and Confers Metal Resistance",J. Biol. Chem. 270, 25079-25086 (1995). Abstract

A Dobi, C Dameron, S Hu, D Hamer, & DR Winge,"Distinct Regions of Cu(I)Ace1 Contacts two Spatially Resolved DNA Major GrooveSites", J. Biol. Chem. 270, 10171-10178 (1995). Abstract

AK Sewell, LT Jensen, JC Erickson, RD Palmiter &DR Winge, "Bioactivity of Metallothionein-3 Correlates with its Novel bDomain Sequence Rather than Metal Binding Properties" Biochem 34,4740- 4747 (1995). Abstract

JL Thorvaldsen, A Sewell, A Tanner, J Peltier, GNGeorge & DR Winge "Mixed Cu+ and Zn2+ coordination in the DNA-binding domain of the AMT1 transcription factor from Candida glabrata", Biochemistry 33, 9566-9577(1994). Abstract

W Yu, V.Santhanagopalan, AK Sewell, LT Jensen, &DR Winge, "Dominance of Metallothionein in Metal Ion Buffering in YeastCapable of Synthesis of (gEC)nG Isopeptides",J. Biol. Chem. 269, 21010-21015 (1994). Abstract

J Erickson, A Sewell, L Jensen, D Winge & R Palmiter,"Enhanced Neurotrophic Activity in Alzheimer's Disease Cortex is not Associatedwith Down-Regulation of Metallothionein III ", Brain Research 649,297-304 (1994). Abstract

G Perez-Alvarado, C Miles, J Michelsen, H Louis, DWinge, M. Beckerle & M Summers, "Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP", Nature Struct Biol 1,388-398 (1994). Abstract

JW.Michelsen, AK Sewell, HA Louis, JI Olsen, DR Davis,DR Winge & MC Beckerle,"Mutational Analysis of the Metal Sites in aLIM Domain Protein" J. Biol. Chem. 269, 11108-11113 (1994). Abstract

J Kosa, JW Michelsen, HA Louis, JI Olsen, DR Davis,MC Beckerle & DR Winge, "Common Metal Ion Coordination in LIM DomainProteins", Biochemistry 33, 468-477 (1994). Abstract

I.Pickering, C.T. Dameron, G. George, I. Dance &D.R. Winge "X-Ray Absorption Spectroscopy of Cuprous-Thiolate MultinuclearClusters", J. Am. Chem. Soc. 115, 9498-9505 (1993).

CT Dameron, P Arnold, V Santhanagopalan, G George,& DR Winge, "Distinct Metal Binding Configurations in Ace1", Biochemistry, 32, 7294-7301 (1993). Abstract

SS Narula, DR Winge & IM Armitage, "Cu and Ag Substituted Yeast Metallothionein: NMR Sequential Assignments ReflectingConformational Heterogeneity at the C-terminus", Biochem. 32,6773-6787 (1993). Abstract

JW Michelsen, KL Schmeichel, MC Beckerle & DRWinge "The LIM Motif Defines a Specific Zinc-Binding Protein Domain", Proc.Natl. Acad. Sci. USA. 90, 4404-4408 (1993). Abstract

JL Thorvaldsen, AK Sewell, C McCowen, & DR Winge"Regulation of Metallothionein Genes by Ace1 and Amt1 Transcription Factors", J. Biol. Chem. 268, 12512-12518 (1993). Abstract
 
 

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